Archive for simulation-based inference

likelihood-free posterior density learning at OWABI [30 April, 1pm GMT+1, 2pm CEST, 8am EST]

Posted in pictures, Running, Statistics, Travel, University life with tags , , , , , , , , , , , , , , , , on April 17, 2026 by xi'an

The next OWABI webinar will take place on 30 April, at 1pm Coventry time (2pm in Paris, 8am in Columbus, Ohio) and will feature

Oksana A. Chkrebtii (Ohio State University)

Likelihood-free Posterior Density Learning for Uncertainty Quantification in Inference Problems
Generative models and those with computationally intractable likelihoods are widely used to describe complex systems in the natural sciences, social sciences, and engineering. Fitting these models to data requires likelihood-free inference methods that explore the parameter space without explicit likelihood evaluations, relying instead on sequential simulation, which comes at the cost of computational efficiency and extensive tuning. We develop an alternative framework called kernel-adaptive synthetic posterior estimation (KASPE) that uses deep learning to directly reconstruct the mapping between the observed data and a finite-dimensional parametric representation of the posterior distribution, trained on a large number of simulated datasets. We provide theoretical justification for KASPE and a formal connection to the likelihood-based approach of expectation propagation. Simulation experiments demonstrate KASPE’s flexibility and performance relative to existing likelihood-free methods including approximate Bayesian computation in challenging inferential settings involving posteriors with heavy tails, multiple local modes, and over the parameters of a nonlinear dynamical system.

OWABI⁷, 25 March 2026: Robust Simulation Based Inference (10am EST time)

Posted in Books, Statistics, University life with tags , , , , , , , , , , , , , , , on March 9, 2026 by xi'an

Speaker:  Larry Wasserman (Carnegie Mellon University)

Title: Robust Simulation Based Inference
Abstract: Simulation-Based Inference (SBI) is an approach to statistical inference where simulations from an assumed model are used to construct estimators and confidence sets. SBI is often used when the likelihood is intractable and to construct confidence sets that do not rely on asymptotic methods or regularity conditions. Traditional SBI methods assume that the model is correct, but, as always, this can lead to invalid inference when the model is misspecified. This paper introduces robust methods that allow for valid frequentist inference in the presence of model misspecification. We propose a framework where the target of inference is a projection parameter that minimizes a discrepancy between the true distribution and the assumed model. The method guarantees valid inference, even when the model is incorrectly specified and even if the standard regularity conditions fail. Alternatively, we introduce model expansion through exponential tilting as another way to account for model misspecification. We also develop an SBI based goodness-of-fit test to detect model misspecification. Finally, we propose two ideas that are useful in the SBI framework beyond robust inference: an SBI based method to obtain closed form approximations of intractable models and an active learning approach to more efficiently sample the parameter space.
Keywords: Exponential tilting, model misspecification, robust inference, simulation based inference, valid inference.
Reference: Lorenzo Tomaselli, Valérie Ventura, Larry Wasserman. Robust Simulation Based Inference. Preprint at ArXiv:2508.02404

OWABI⁷, 26 February 2026: Prequential posteriors (11am UK time)

Posted in Books, Statistics, University life with tags , , , , , , , , , , , , , , on February 25, 2026 by xi'an

Speaker:  Shreya Sinha Roy (University of Warwick)

Title: Prequential posteriors
Abstract: Data assimilation is a fundamental task in updating forecasting models upon observing new data, with applications ranging from weather prediction to online reinforcement learning. Deep generative forecasting models (DGFMs) have shown excellent performance in these areas, but assimilating data into such models is challenging due to their intractable likelihood functions. This limitation restricts the use of standard Bayesian data assimilation methodologies for DGFMs. To overcome this, we introduce prequential posteriors, based upon a predictive-sequential (prequential) loss function; an approach naturally suited for temporally dependent data which is the focus of forecasting tasks. Since the true data-generating process often lies outside the assumed model class, we adopt an alternative notion of consistency and prove that, under mild conditions, both the prequential loss minimizer and the prequential posterior concentrate around parameters with optimal predictive performance. For scalable inference, we employ easily parallelizable wastefree sequential Monte Carlo (SMC) samplers with preconditioned gradient-based kernels, enabling efficient exploration of high-dimensional parameter spaces such as those in DGFMs. We validate our method on both a synthetic multi-dimensional time series and a real-world meteorological dataset; highlighting its practical utility for data assimilation for complex dynamical systems.
Keywords: diffusion models, simulation based inference, sequential methods.
Reference: S. S. Roy, R. Everitt, C. P Robert, R. Dutta. Prequential posteriors. Preprint at ArXiv:2511.17721, 202

London Meeting on Computational Statistics 28-29 April 2026, plus a UCL lecture by Lester Mackey

Posted in Books, pictures, Statistics, Travel, University life with tags , , , , , , , , , , , , , , on February 6, 2026 by xi'an

OWABI⁷, 29 January 2026: Sequential Neural Score Estimation (11am UK time)

Posted in Books, Statistics, University life with tags , , , , , , , , , , on January 21, 2026 by xi'an

Speaker: Louis Sharrock (University College London)

Title: Sequential Neural Score Estimation: Likelihood-free inference with conditional score base diffusion models
Abstract: We introduce Sequential Neural Posterior Score Estimation (SNPSE), a score-based method for Bayesian inference in simulator-based models. Our method, inspired by the remarkable success of score-based methods in generative modelling, leverages conditional score-based diffusion models to generate samples from the posterior distribution of interest. The model is trained using an objective function which directly estimates the score of the posterior. We embed the model into a sequential training procedure, which guides simulations using the current approximation of the posterior at the observation of interest, thereby reducing the simulation cost. We also introduce several alternative sequential approaches, and discuss their relative merits. We then validate our method, as well as its amortised, non-sequential, variant on several numerical examples, demonstrating comparable or superior performance to existing state-of-the-art methods such as Sequential Neural Posterior Estimation (SNPE).
Keywords: diffusion models, simulation based inference, sequential methods.
Reference: L. Sharrock, J. Simons, S. Liu, M. Beaumont, Sequential Neural Score Estimation: Likelihood-Free Inference with Conditional Score Based Diffusion Models. PLMR, 235, 44565-44602, 2024.