Archive for genome

unscrambling Scottish eggs for wildcats

Posted in Books, Kids, pictures, Statistics, Travel, University life with tags , , , , , , , , , , , , , , , on January 17, 2024 by xi'an


Read in Nature (and The Guardian) a report on the attempt to rewild the Scottish wildcat population due to its current high levels of domestic-cat DNA resulting from decades of interbreeding with domestic cats gone feral, even though this happened only relatively recently, in the 1960′. Thanks, rather paradoxically, to the 150 captive wildcats found in zoos and parks across the UK, more preserved from this interbreeding, by selective breeding towards removing hybrid segments of DNA from the genome of the kittens. The attempt is operated by Saving Wildcats, who have already released 19 wildcats in the Cairngorms.

“However, the project will not be a quick or an easy one”, said programme scientist Prof Mark Beaumont of Bristol University. “The idea would be to have funds to monitor what is happening in the kittens as you progress, and that costs money. A whole genome of an individual cat sets you back about $200.” The Guardian Sun 10 Dec 2023

The project is backed up by a scientific analysis of the chances of rewilding, written by Daniel J. Lawson, Jo Howard-McCombe, Mark Beaumont, and Helen Senn. (While the paper includes a modelling of the meiosis process via a simulation experiment, no ABC were harmed in running it!)

Balto’s genome

Posted in Books, Kids, pictures, Travel with tags , , , , , , , , , , , , , , , on May 5, 2023 by xi'an

Darwin’s radio [book review]

Posted in Books, Kids, pictures, University life with tags , , , , , , , , , , , , , , , , on September 10, 2016 by xi'an

When in Sacramento two weeks ago I came across the Beers Books Center bookstore, with a large collection of used and (nearly) new cheap books and among other books I bought Greg Bear’s Darwin Radio. I had (rather) enjoyed another book of his’, Hull Zero Three, not to mention one of his first books, Blood Music, I read in the mid 1980’s, and the premises of this novel sounded promising, not mentioning the Nebula award. The theme is of a major biological threat, apparently due to a new virus, and of the scientific unraveling of what the threat really means. (Spoilers alert!) In that respect it sounds rather similar to the (great) Crichton‘s The Andromeda Strain, which is actually mentioned by some characters in this book. As is Ebola, as a sort of contrapoint (since Ebola is a deadly virus, although the epidemic in Western Africa now seems to have vanished). The biological concept exploited here is dormant DNA in non-coding parts of the genome that periodically get awaken and induce massive steps in the evolution. So massive that carriers of those mutations are killed by locals. Until the day it happens in an all-connected World and the mutation can no longer be stopped. The concept is compelling if not completely convincing of course, while the outcome of a new human race, which is to Homo Sapiens what Homo Sapiens was to Neanderthal, is rather disappointing. (How could it be otherwise?!) But I did appreciate the postulate of a massive and immediate change in the genome, even though the details were disputable and the dismissal of Dawkins‘ perspective poorly defended. From a stylistic perspective, the style is at time heavy, while there are too many chance occurrences, like the main character happening to be in Georgia for a business deal (spoilers, spoilers!) at the times of the opening of collective graves, or the second main character coming upon a couple of Neanderthal mummies with a Sapiens baby, or yet this pair of main characters falling in love and delivering a live mutant baby-girl. But I enjoyed reading it between San Francisco and Melbourne, with a few hours of lost sleep and work. It is a page turner, no doubt! I also like the political undercurrents, from riots to emergency measures, to an effective dictatorship controlling pregnancies and detaining newborns and their mothers.

One important thread in the book deals with anthropology digs getting against Native claims to corpses and general opposition to such digs. This reminded me of a very recent article in Nature where a local Indian tribe had claimed rights to several thousand year old skeletons, whose DNA was then showed to be more related with far away groups than the claimants. But where the tribe was still granted the last word, in a rather worrying jurisprudence.